Synaptonemal complex central element protein 1 [Mus musculus (house mouse)]

Reviewed functional gene

1. Abstract
In mammals, the synaptonemal complex is a structure required to complete crossover recombination. Although suggested by cytological work, in vivo links between the structural proteins of the synaptonemal complex and the ... In mammals, the synaptonemal complex is a structure required to complete crossover recombination. Although suggested by cytological work, in vivo links between the structural proteins of the synaptonemal complex and the proteins of the recombination process have not previously been made. The central element of the synaptonemal complex is traversed by DNA at sites of recombination and presents a logical place to look for interactions between these components. There are four known central element proteins, three of which have previously been mutated. Here, we complete the set by creating a null mutation in the Syce1 gene in mouse. The resulting disruption of synapsis in these animals has allowed us to demonstrate a biochemical interaction between the structural protein SYCE2 and the repair protein RAD51. In normal meiosis, this interaction may be responsible for promoting homologous synapsis from sites of recombination. PMID: [19247432]  

1000G (Phase 3): 74   ESP6500 (SI-V2): 58   ExAC (r0.3.1): 247   dbSNP(Build 147): 313

Chinese health control (254): 9  European health control (283): 8   Chinese patients (168):  

Click the right sign for more information