FertilityOnline | Spermatogenes

Detail Information of SG001686

General information

SG ID

SG001686

Gene Name

Serpina5

Gene Synonyms/Alias

4933415L04, PAI-3, Pci

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

ENSMUSG00000041550

Ensembl Protein ID

ENSMUSP00000021495

Description

Serine (or cysteine) peptidase inhibitor, clade A, member 5 [Mus musculus (house mouse)]

Orthology

Species	Uniprot	Gene stable ID	Gene Name
Rattus norvegicus	F7EMJ6	RGD:619817	Serpina5
Gallus gallus	R4GGU3	Ensembl:ENSGALG00000028598	LOC107049127
Gallus gallus	E1C7T1	Ensembl:ENSGALG00000023070	SERPINA1

More Orthology >>

Status

Reviewed functional gene

Functional information

Function in Stage	premeiotic meiotic postmeiotic
Function in Cell Type	Elongated spermatid Sertoli cell Spermatocyte
The information of related literature	1. Abstract Protein C inhibitor (PCI) is a nonspecific, heparin-binding serpin (serine protease inhibitor) that inactivates many plasmatic and extravascular serine proteases by forming stable 1 PMID: [11120760] 2. Abstract OBJECTIVE OBJECTIVE PMID: [17434507]
Figures for illustrating the function of this protein/gene	P. Uhrin, M. Dewerchin, M. Hilpert, P. Chrenek, C. Schofer, M. Zechmeister-Machhart, G. Kronke, A. Vales, P. Carmeliet, B. R. Binder and M. Geiger (2000) Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest 106(12): 1531-9. PMID: [11120760] P. Uhrin, M. Dewerchin, M. Hilpert, P. Chrenek, C. Schofer, M. Zechmeister-Machhart, G. Kronke, A. Vales, P. Carmeliet, B. R. Binder and M. Geiger (2000) Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest 106(12): 1531-9. PMID: [11120760] P. Uhrin, M. Dewerchin, M. Hilpert, P. Chrenek, C. Schofer, M. Zechmeister-Machhart, G. Kronke, A. Vales, P. Carmeliet, B. R. Binder and M. Geiger (2000) Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J Clin Invest 106(12): 1531-9. PMID: [11120760]
Functional description	-
Protein complex
Pathway	ReactomeID: R-MMU-140875 Common Pathway of Fibrin Clot Formation
Human diseases
OMIM
Spermatogenesis failure	N/A

Expression and location

Tissue specificity (in Homo sapiens)	Expressed highest in testis
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatogonium
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Secreted, extracellular space

Mutation in human orthology

Variants founded in public databases

1000G (Phase 3): 889 ESP6500 (SI-V2): 92 ExAC (r0.3.1): 380 dbSNP(Build 147): 1899

Variants founded in in-house datasets

Chinese health control (254): 23 European health control (283): 19 Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
SERPINA5	0.00001761	0.0000183093

Other information

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0007283	spermatogenesis	IMP
Biological Process	GO:0010466	negative regulation of peptidase activity	IEA
Biological Process	GO:0010951	negative regulation of endopeptidase activity	IEA
Biological Process	GO:0045861	negative regulation of proteolysis	IEA
Biological Process	GO:0051346	negative regulation of hydrolase activity	IEA
Biological Process	GO:0061107	seminal vesicle development	IEA
Cellular Component	GO:0002080	acrosomal membrane	IEA
Cellular Component	GO:0005576	extracellular region	IEA
Cellular Component	GO:0005615	extracellular space	IEA
Cellular Component	GO:0009897	external side of plasma membrane	IEA
Cellular Component	GO:0016020	membrane	IEA
Cellular Component	GO:0031091	platelet alpha granule	IEA
Cellular Component	GO:0031094	platelet dense tubular network	IEA
Cellular Component	GO:0036024	protein C inhibitor-TMPRSS7 complex	IEA
Cellular Component	GO:0036025	protein C inhibitor-TMPRSS11E complex	IEA
Cellular Component	GO:0036026	protein C inhibitor-PLAT complex	IEA
Cellular Component	GO:0036027	protein C inhibitor-PLAU complex	IEA
Cellular Component	GO:0036028	protein C inhibitor-thrombin complex	IEA
Cellular Component	GO:0036029	protein C inhibitor-KLK3 complex	IEA
Cellular Component	GO:0036030	protein C inhibitor-plasma kallikrein complex	IEA
Cellular Component	GO:0043234	protein complex	IEA
Cellular Component	GO:0070062	extracellular exosome	IEA
Cellular Component	GO:0097181	protein C inhibitor-coagulation factor V complex	IEA
Cellular Component	GO:0097182	protein C inhibitor-coagulation factor Xa complex	IEA
Cellular Component	GO:0097183	protein C inhibitor-coagulation factor XI complex	IEA
Molecular Function	GO:0001972	retinoic acid binding	IEA
Molecular Function	GO:0002020	protease binding	IEA
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IEA
Molecular Function	GO:0005515	protein binding	IPI
Molecular Function	GO:0030414	peptidase inhibitor activity	IEA
Molecular Function	GO:0031210	phosphatidylcholine binding	IEA
Molecular Function	GO:0032190	acrosin binding	IEA

Protein-Protein interaction information

Protein A	Gene name A	Protein B	Gene name B	Evidence
ENSMUSP00000021495	Serpina5	ENSMUSP00000021496	Serpina3a	predicted
ENSMUSP00000021495	Serpina5	ENSMUSP00000021530	Hif1a	predicted
ENSMUSP00000021495	Serpina5	ENSMUSP00000021606	Atxn3	experimental

More PPIs >>

Protein family and Domain

P70458