FertilityOnline | Spermatogenes

Detail Information of SG001751

SG ID

SG001751

Gene Name

Rnf133

Gene Synonyms/Alias

Greul2

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

Ensembl Protein ID

Description

Ring finger protein 133 [Mus musculus (house mouse)]

Orthology

Status

Reviewed functional gene

Function in Stage	postmeiotic
Function in Cell Type	Spermatid
The information of related literature	1. Abstract PMID: [18574499]
Figures for illustrating the function of this protein/gene	H. Nian, W. Zhang, H. Shi, Q. Zhao, Q. Xie, S. Liao, Y. Zhang, Z. Zhang, C. Wang and C. Han (2008) Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase. Cell Res 18(7): 800-2. PMID: [18574499]
Functional description	-
Protein complex
Pathway
Human diseases
OMIM
Spermatogenesis failure	N/A

Tissue specificity (in Homo sapiens)	Expressed highest in testis
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatid
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Endoplasmic reticulum membrane

Variants founded in public databases

1000G (Phase 3): 32 ESP6500 (SI-V2): 49 ExAC (r0.3.1): 262 dbSNP(Build 147): 296

Variants founded in in-house datasets

Chinese health control (254): European health control (283): 1 Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
RNF133	0.000013705	0.0000135394

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Sub-Ontologies	Accession	Term	Evidence
Biological Process	GO:0016567	protein ubiquitination	IEA
Biological Process	GO:0051865	protein autoubiquitination	IDA
Cellular Component	GO:0005783	endoplasmic reticulum	IEA
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA
Cellular Component	GO:0016020	membrane	IEA
Cellular Component	GO:0016021	integral component of membrane	IEA
Molecular Function	GO:0003674	molecular_function	ND
Molecular Function	GO:0008270	zinc ion binding	IEA
Molecular Function	GO:0016740	transferase activity	IEA
Molecular Function	GO:0046872	metal ion binding	IEA

Protein-Protein interaction information

Protein family and Domain