FertilityOnline | Spermatogenes

Detail Information of SG006281

SG ID

SG006281

Gene Name

RPA3

Gene Synonyms/Alias

REPA3, RP-A p14

Organism

Homo sapiens

NCBI Taxonomy ID

9606

Ensembl Gene ID

Ensembl Protein ID

Description

replication protein A3 [Homo sapiens (human)]

Orthology

Status

Candidate fucntional gene (Orthology matched)

Function in Stage

Function in Cell Type

The information of related literature

Figures for illustrating the function of this protein/gene

Functional description

Protein complex

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Complex name	Subunits(UniProt IDs)	Functional comment
BRAFT complex	P54132 O15360 Q00597 Q9HB96 Q9NPI8 O15287 Q9NW38 P40692 Q9H9A7 P27694 P15927 P35244 Q13472
BRAFT complex	P54132 O15360 Q00597 Q9HB96 Q9NPI8 O15287 Q9NW38 P27694 P15927 P35244 Q13472
RC complex during S-phase of cell cycle	P20248 P24941 P18858 P09874 P09884 P28340 Q07864 P35251 P35250 P27694 P15927 P35244 P11387	CDK2 associates with the RC complex only during the S-phase of the cell cycle, but disappeares in the G2-phase.
RC complex during G2/M-phase of cell cycle	P20248 P14635 P06493 P09874 P09884 P28340 Q07864 P35251 P35250 P27694 P15927 P35244 P11387	CDK1 and cyclin B1 associate with RC complex only during G2/M-phase of cell cycle. DNA ligase I is not found in the RC complex during G2/M-phase.
BLM complex II	P54132 Q9H9A7 P27694 P15927 P35244 Q13472	BLAP75 is an integral component of BLM complexes and is essential for their stability.
BLM complex II	P54132 Q9H9A7 P27694 P15927 P35244 Q13472
RPA complex	P27694 P15927 P35244	RPA facilitates unwinding of dsDNA.

Pathway

ReactomeID: R-HSA-912446
Meiotic recombination

Human diseases

OMIM

Spermatogenesis failure

Tissue specificity (in Homo sapiens)	Expressed highest in lymph node
Testicular Cell specificity (in Mus musculus)	Expressed highest in sertoli cell
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Nucleus.

Variants founded in public databases	1000G (Phase 3): 2698 ESP6500 (SI-V2): 38 ExAC (r0.3.1): 239 dbSNP(Build 147): 5395
Variants founded in in-house datasets	Chinese health control (254): 2 European health control (283): 3 Chinese patients (168):
De novo Mutation Rate	Gene Name: RPA3 DNMR-average: 0.0000050535 DNMR-SC: 0.00000556613

Protein-Protein interaction information

Protein family and Domain