FertilityOnline | Spermatogenes

Detail Information of SG010033

SG ID

SG010033

Gene Name

CCT7

Gene Synonyms/Alias

CCTETA, CCTH, NIP7-1, TCP1ETA

Organism

Homo sapiens

NCBI Taxonomy ID

9606

Ensembl Gene ID

Ensembl Protein ID

Description

chaperonin containing TCP1 subunit 7 [Homo sapiens (human)]

Orthology

Status

Candidate fucntional gene (Orthology matched)

Function in Stage

Function in Cell Type

The information of related literature

Figures for illustrating the function of this protein/gene

Functional description

Protein complex

Complex name	Subunits(UniProt IDs)	Functional comment
CCT micro-complex	P17987 P78371 P49368 P50991 P48643 P40227 Q99832 P50990	The chaperonins are a family of molecular chaperones involved in protein folding, assembly and transport. The chaperonin-containing TCP-1 (CCT) is abundant in eukaryotic cytosol. CCT micro-complexes have mol. wts ranging from 120 to 250 kDa and are present in cells at lower abundance (<5%) as compared with intact CCT.

Pathway

ReactomeID: R-HSA-6814122
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Human diseases

OMIM

Spermatogenesis failure

Tissue specificity (in Homo sapiens)	Expressed highest in testis
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatocyte
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Cytoplasm

Variants founded in public databases	1000G (Phase 3): 528 ESP6500 (SI-V2): 108 ExAC (r0.3.1): 523 dbSNP(Build 147): 1477
Variants founded in in-house datasets	Chinese health control (254): 5 European health control (283): 1 Chinese patients (168):
De novo Mutation Rate	Gene Name: CCT7 DNMR-average: 0.0000221775 DNMR-SC: 0.0000217339

GO
Protein-Protein interaction information
Protein family and Domain	Q99832