PLAG1 (PLAG1 Zinc Finger) is a Protein Coding gene encodes a zinc finger protein with 2 putative nuclear localization signals.PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. pleomorphic adenoma gene 1 (PLAG1), whose gene product, a zinc finger transcription factor, is best known for its involvement in the development of various human cancers via stimulation of cell proliferation. PLAG1 is believed to play a key role in regulating aspects of reproduction and Mice with targeted dis-ruption of both alleles of Plag1 are characterised by reduced fertility in both sexes.
