FertilityOnline | Spermatogenes

Detail Information of SG028306

SG ID

SG028306

Gene Name

Cry1

Gene Synonyms/Alias

AU020726, AU021000, Phll1

Organism

Mus musculus

NCBI Taxonomy ID

10090

Ensembl Gene ID

Ensembl Protein ID

Description

cryptochrome 1 (photolyase-like) [Mus musculus (house mouse)]

Orthology

Status

Reviewed functional gene

Function in Stage	meiotic postmeiotic premeiotic
Function in Cell Type	Sertoli cell Spermatid Spermatocyte
The information of related literature
Figures for illustrating the function of this protein/gene	PMID: [29411926] PMID: [29411926] PMID: [29411926] PMID: [29411926] PMID: [29411926] PMID: [29411926]
Functional description	Cryptochrome (Cry)1 is essential for generating circadian rhythm in central and many peripheral oscillators. Cry1 is necessary for normal testicular function and its deficiency increased testicular germ cell apoptosis and decreased sperm count. Dysregulation of Cry1 and male reproductive defects in mice, indicating that Cry1 plays a critical role in maintaining normal testicular function.
Protein complex
Pathway	ReactomeID: R-MMU-508751 Circadian Clock
Human diseases
OMIM
Spermatogenesis failure

Tissue specificity (in Homo sapiens)	Expressed highest in testis
Testicular Cell specificity (in Mus musculus)	Expressed highest in spermatocyte
Testicular scRNA-seq (in Homo sapiens)	View detail
Testicular scRNA-seq (in Mus musculus)	View detail
Subcellular location	Cytoplasm. Nucleus

Variants founded in public databases

1000G (Phase 3): 2771 ESP6500 (SI-V2): 86 ExAC (r0.3.1): 529 dbSNP(Build 147): 5921

Variants founded in in-house datasets

Chinese health control (254): 6 European health control (283): 5 Chinese patients (168):

De novo Mutation Rate

Gene Name	DNMR-average	DNMR-SC
CRY1	0.000023525	0.0000246411

GO
Protein-Protein interaction information
Protein family and Domain	P97784