EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit) is a Protein Coding gene that encodes a member of the Polycomb-group (PcG) family. Regarded as PRC2's canonical methyltransferase, EZH2 plays a major role in catalyzing di- or tri-methylation of H3K27 in many cell types. Loss of Ezh2 results in embryonic lethality.
Complex name
Subunits(UniProt IDs)
Functional comment
Ezh2 methyltransferase complex, cytosolic
O75530 Q61188 Q15022
ReactomeID: R-MMU-8943724 Regulation of PTEN gene transcription
